Effects of Intracameral Injection of Phenylephrine - Cyclopentolate and Tropicamide-Lidocaine Hydrochloride Combinations on Ophthalmologic and Cardiovascular Parameters in Healthy Cats

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Authors

  • Osman Bulut

Keywords:

Heart rate, intraocular pressure, mean arterial pressure, mydriatics, pupil diameter

Abstract

In this study, it is aimed to investigate the effects of intracameral mydriatic combinations on the pupil dilation (PD), intraocular pressure (IOP), heart rate (HR) and mean arterial pressure (MAP). In this study 35 animals were divided into 5 groups. The first group (MSic) was phenylephrine hydrochloride (Mydfrin) and cyclopentolate hydrochloride (Sikloplejin),  the second group (TLic) was tropicamide (Tropamid) and 2% lidocaine,  the third group (BSS) was balanced salt solution. Cats were anesthetized, and all solutions were injected intracamerally. The fourth group (MSt) was phenylephrine hydrochloride (Mydfdrin) and cyclopentolate hydrochloride (Sikloplejin) and the fifth group (TLt) tropicamide (Tropamid) and 2% lidocaine were given by topically. During this research, the fastest onset of the mydriasis was numerically formed by first group. All intracameral groups were seen having longer duration of mydriasis compared to topical groups. Intraocular pressure decreased after anterior camera paracentesis in all intracameral procedures. In our study, time dependent changes of heart rate were found to be statistically significant in all groups. Our research observed that first and second group successfully created enough mydriasis (>10mm). In terms of pupil diameter, it has been proven that first and second group are usable alternatives administration, and no side effects on intraocular pressure, heart rate or mean arterial pressure.

References

Agin H, Gercek G, Kutlu A, Gulez N. 2008. Topikal siklopentolat kullanımına baglı gelisen deliryum tablosu: Bir vaka takdimi. Cocuk Sagligi ve Hastaliklari Dergisi, 51: 39-42.

Ayintap E, Keskin U, Coskun M, Ilhan O, Semiz H, Oksuz H. 2011. Katarakt Cerrahisi Oncesi Kullanılan Topikal %2,5'luk Fenilefrin HCI Damlanin Sistemik Kan Basincina Etkisi. Turk Oftalmoloji Dergisi, 41: 164-166.

Amorim TM, Dower NMB, Stocco MB, Pizoni LM, Ribeiro AP. 2019. Effects of intracameral injection of epinephrine and 2% lidocaine on pupil diameter, intraocular pressure, and cardiovascular parameters in healthy cats. Veterinary Ophthalmology, 22: 276–283.

Behndig A, Korobelnik JF. 2015. Mydriatic insert and intracameral injections compared with mydriatic eyedrops in cataract surgery: controlled studies. The Journal of Cataract & Refractive Surgery, 41: 1503-1519.

Bilgin G, Demir G. 2015. Midriyatik Göz Damlaları ve Bilişsel Fonksiyonlar. MN Oftalmology, 22: 43-45.

Deeks ED. 2019. Tropicamide / Phenylephrine / Lidocaine Intracameral Injection: A Review in Cataract Surgery. Clinical Drug Investigation, 39: 1133–1139.

Kim EC, Park SH, Kim MS. 2010. A comparison of pupil dilation and induction of corneal endothelial apoptosis by intracameral 1% lidocaine versus 1:100 000 epinephrine in rabbits. Journal of Ocular Pharmacology and Therapeutics, 26: 563-570.

Liou SW, Chen CC. 2001. Maintenance of mydriasis with one bolus of epinephrine injection during phacoemulsification. Journal of Ocular Pharmacology and Therapeutics, 17: 249–253.

Lundberg B, Behndig A. 2003. Intracameral mydriatics in phacoemulsification cataract surgery. The Journal of Cataract & Refractive Surgery, 29: 2366–2371.

Lundberg B, Behndig A. 2008. Separate and additive mydriatic effects of lidocaine hydrochloride, phenylephrine, and cyclopentolate after intracameral injection. The Journal of Cataract & Refractive Surgery, 34: 280–283.

Myers GW, Shugar JK. 2009. Optimizing the intracameral dilation regimen for cataract surgery: Prospective randomized comparison of 2 solutions. The Journal of Cataract & Refractive Surgery, 35: 273–276.

Nikeghbali A, Falavarjani KG, Kheirkhah A, Bakhtiari P, Kashkouli MB. 2007. Pupil dilation with intracameral lidocaine during phacoemulsification. The Journal of Cataract & Refractive Surgery, 33: 101-103.

Nikeghbali A, Falavarjani KG, Kheirkhah A. 2008. Pupil dilation with intracameral lidocaine during phacoemulsification: benefits for the patient and surgeon. Indian Journal of Ophthalmology, 56: 63–64.

Nuijts RM, Mencucci R, Viaud-Quentric K, Elena PP, Olmiere C, Behndig A. 2017. Ocular tolerance in rabbits after intracameral administration of a fixed combination of tropicamide, phenylephrine, and lidocaine with and without rinsing. The Journal of Cataract & Refractive Surgery, 43: 673–679.

Osinchuk SC, Salpeter EM, Lavalle G, Leisi ML, Sandmeyer LS. 2020. Effect of intracameral epinephrine on heart rate, post-operative ocular hypertension, and long-term outcome following canine phacoemulsification. Veterinary Ophthalmology, 00: 1–7.

Park SA, Kim NR, Park YW, Jeong MB, Kim WT, Kim SE, Kim TH, Seo KM. 2009. Evaluation of the mydriatic effect of intracameral lidocaine hydrochloride injection in eyes of clinically normal dogs. American Journal of Veterinary Research, 70: 1521-1525.

Pypendop BH, Ilkiw JE. 2005. Assessment of the hemodynamic effects of lidocaine administered IV in isoflurane-anesthetized cats. American Journal of Veterinary Research, 66: 661-668.

Soong T, Soultanidis M, Claoue C, Gallagher M, Thomson S. 2006. Safety of intracameral mydriasis in phacoemulsification cataract surgery. The Journal of Cataract & Refractive Surgery, 32: 375–377.

Srinivasan S. 2018. Intracameral mydriatics during cataract surgery. The Journal of Cataract & Refractive Surgery, 44: 257–258.

Stadtbaumer K, Frommlet F, Nell B. 2006. Effects of mydriatics on intra-ocular pressure and pupil size in the normal feline eye. Veterinary Ophthalmology, 9: 233-237.

Stavert B, McGuinness MB, Harper CA, Guymer RH, Finger RP. 2015. Cardiovascular adverse effects of phenylephrine eyedrops: a systematic review and meta-analysis. JAMA Ophthalmology, 133: 647–652.

Williams GS, Radwan M, Kadare S, Williams CP. 2012. The short to medium-term risks of intracameral phenylephrine. Middle East African Journal Ophthalmology. 19: 357–360.

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Published

2022-12-20

How to Cite

Bulut, O. (2022). Effects of Intracameral Injection of Phenylephrine - Cyclopentolate and Tropicamide-Lidocaine Hydrochloride Combinations on Ophthalmologic and Cardiovascular Parameters in Healthy Cats. International Journal of Veterinary and Animal Research (IJVAR), 5(3), 129–133. Retrieved from https://ijvar.org/index.php/ijvar/article/view/553

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Research Articles