Silymarin Ameliorates Valproic Acid-Induced Pancreas Injury by Decreasing Oxidative Stress

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  • Ibrahim Aktas adıyaman üniversitesi
  • Fatih Mehmet Gur
  • Meltem Ozgecmen


Pancreas injury, rat, silymarin, valproic acid.


In this study, the protective effects of silymarin (SLY) against valproic acid (VPA) induced pancreatic damage were investigated using histological and biochemical parameters in rats. The experiment was performed with 21 Sprague Dawley male rats. Rats were divided into three groups: Group 1 control; group 2 VPA; group 3 VPA + SLY. 1 mL saline to the control group; VPA group, 500 mg / kg / day VPA; VPA + SLY group 500 mg / kg / day VPA and 100 mg / kg / day SLY were administered via gavage. Serum amylase and lipase levels increased with VPA application were reversed with SLY application. In addition, with VPA application, malondialdehyde (MDA) increased and glutathione (GSH) levels reduced in pancreatic tissue. This situation was significantly (p ≤ 0.05) suppressed with the application of SLY. Histopathological changes (acinar cell degeneration, hemorrhage, infiltration, necrosis and shrinkage in langerhans islets) in the pancreas. Reaktif oxygene species (ROS) and histopathological changes decreased and antioxidant activity increased in VPA + SLY group compared to VPA group. The results obtained in this study; SLY can protect against VPA-induced pancreatic damage and can also be a pharmacological agent with therapeutic properties.




How to Cite

Aktas, I., Gur, F. M., & Ozgecmen, M. (2020). Silymarin Ameliorates Valproic Acid-Induced Pancreas Injury by Decreasing Oxidative Stress. International Journal of Veterinary and Animal Research (IJVAR), 3(2), 34–38. Retrieved from



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