Propolis: The Role of Propolis in CancerAbstract views: 82 / PDF downloads: 53
Keywords:Anti-cancer, apitherapy, cytotoxicity, propolis
Propolis is a resinous natural product produced by honey bees by mixing collected buds and exudates of plants with bee wax. Bees use propolis to protect themselves against wind and rain by using it to construct and repair hives. Propolis has a wide range of biological effects as it is a mixture of natural substances, and it is widely used for its anti-inflammatory, anti-oxidant, immunomodulatory, and anti-cancer effects. Propolis has been used in traditional medicine since time immemorial. Research studies on the anti-tumor effects of propolis extracts and components such as flavonoids, phenolic acids, and their esters demonstrate their potential to be used in the development of new anti-tumor agents. Propolis shows an anti-carcinogenic effect against cancers of the brain, head and neck, skin, breast, liver, pancreas, kidney, bladder, prostate, colon, and blood. In-vivo and in-vitro studies have shown that propolis has cytotoxic, anti-genotoxic or anti-mutagenic, anti-proliferative, anti-angiogenic, anti-metastatic, and proapoptotic properties. Its main mechanisms in cancer treatment can be explained as prevention of metastasis, arrest of the cell cycle, induction of apoptosis and alleviation of harmful side effects caused by chemotherapy. The beneficial effects of natural products on human health have been reported in studies to prevent tumor formation and/or suppress the growth of tumors into cancer. In this review, detailed information about the properties, biological effects, and anti-cancer effects of propolis was given by reviewing current literatures.
Ahangari Z, Naseri M, Vatandoost F. 2018. Propolis: Chemical composition and its applications in endodontics. Iran Endodontic Journa. 13(3): 285-292.
Aktaş SH, Akbulut H. 2014. Kolorektal kanserde anjiyogenez ve antianjiyogenik tedaviler. Türk Onkoloji Dergisi. 29(2): 67-79.
Albayrak S. Albayrak S. 2008. Propolis: Doğal antimikrobiyal madde. Ankara Eczacılık Fakültesi Dergisi. 37 (3): 201-215.
Anjum SI, Ullah A, Khan KA, Attaullah M, Khan H, Ali H, Bashir MA, Tahir M, Ansari MJ, Ghramh HA, Adgaba N, Dash CK. 2019. Composition and functional properties of propolis (beeglue): A review. Saudi Journal Biology. 26(7): 1695-1703.
Aus G, Abbou CC, Bolla M, Heidenreich A, Schmid HP, Van Poppel H, Wolff J, Zattoni F. 2005. EAU guidelines on prostate cancer. European Association of Urology. 48(4): 546-551.
Awale S, Li F, Onozuka H, Esumi H, Tezuka Y, Kadota S. 2008. Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Bioorganic&medicinal Chemistry. 16(1): 181-189.
Bankova V, Popova M, Trusheva B. 2018. The phytochemistry of the honey bee. Phytochemistry. 155(9): 1-11.
Baskar R, Dai J, Wenlong N, Yeo R, Yeoh KW. 2014. Biological response of cancer cells to radiation treatment. Frontiers in Molecular Biosciences. 1(24): 1-9.
Baykara O. 2016. Kanser tedavisinde güncel yaklaşımlar. Balıkesir Sağlık Bilimleri Dergisi. 5(3): 154-165.
Beauregard AP, Harquail J, Lassalle-Claux G, Belbraouet M, Jean-Francois J, Touaibia M, Robichaud GA. 2015. CAPE analogs induce growt harrest and apoptosis in breast cancer cells. Molecules. 20(7): 12576-12589.
Benguedouar L, Lahouel M, Gangloff S, Durlach A, Grange F, Bernard P, Antonicelli F. 2015. Algerian ethanolic extract of propolis and galangin decreased melanoma tumour progression in C57BL6 mice. Annales de Dermatologie et de Vénéréologie 142(6-7): S294.
Bozyel ME, Bozyel EM, Canlı K, Altuner EM. 2019. Anti-canceruses of medicinal plants in Turkish traditional medicine. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi. 22: 465-484.
Chiu HF, Han YC, Shen YC, Golovinskaia O, Venkatakrishnan K, Wang CK. 2020. Chemopreventive and chemotherapeutic effect of propolis and ıts constituents: A Mini-review. Journal of Cancer Prevention, 25(2): 70-78.
Cornara L, Biagi M, Xiao J, Burlando B. 2017. Therapeutic properties of bioactive compounds from different honeybee products. Frontiers in pharmacology. 8: 412.
Carocho M, Ferreira IC. 2013. The role of phenolic compounds in the fight against cancer-A review. Anti-Cancer Agents in Medicinal Chemistry. 13(8): 1236-1258.
Daleprane JB, Abdalla DS. 2013. Emerging roles of propolis: antioxidant, cardioprotective, and antiangiogenic actions. Evidence-based Complementary and Alternative Medicine. 8s. ID175135.
Damodaran T. 2021. Propolis. In Nutra ceuticals. 795-812. Second ed. Academic Press, Amsterdam, The Netherlands, https://doi.org/10.1016/B978-0-12-821038-3.00046-X.
De-Groot AC. 2013. Propolis: a review of properties, applications, chemical composition, contactallergy, and other adverse effects. Dermatitis. 24(6): 263-282.
Desai AG, Qaz GN, Ganju RK, El-Tamer M, Singh J, Saxena AK, Bhat HK. 2008. Medicinal plants and cancer chemoprevention. Current drug metabolism, 9(7): 581-591.
Doğan N, Hayoğlu İ. 2012. Propolis ve kullanım alanları. Harran Tarım ve Gıda Bilimleri Dergisi. 16(3): 39-48.
Huang S, Zhang CP, Wang K, Li GQ, Hu FL. 2014. Recent advances in the chemical composition of propolis. Moleküller. 19(12): 19610-19632.
Ibrahim R, El-Banna AA. 2021. Network pharmacology-based analysis for unraveling potential cancer-related molecular targets of Egyptian propolis phytoconstituents accompanied with molecular docking and in vitro studies. RSC Advances, 11(19): 11610-11626.
Keshavarz M, Mostafaie A, Mansouri K, Shakiba Y, Motlagh HRM. 2009. Inhibition of corneal neovascularization with propolis extract. Archives of Medical Research, 40: 59-61.
Król W, Bankova V, Sforcin JM, Szliszka E, Czuba Z, Kuropatnicki AK. 2013. Propolis: Propertıes, applıcatıon and its potential. Evıdence-Based Complementary and Alternatıve Medicine. Article ID: 807578. doi: http://dx.doi.org/10.1155/2013/807578
Kubiliene L, Laugaliene V, Pavilonis A, Maruska A, Majiene D, Barcauskaite K, Savickas A. 2015. Alternative preparation of propolis extracts: comparison of their composition and biological activities. BMC complementary and Alternative Medicine. 15(1): 1-7.
Kumova Ü. 2002. Önemli bir arı ürünü: Propolis. Uludağ Arıcılık Dergisi. 2(2): 10-24.
Kurek-Górecka A, Rzepecka-Stojko A, Górecki M, Stojko J, Sosada M, ŚwierczekZięba, G. 2014. Structure and antioxidant activity of polyphenols derived from propolis. Molecules, 19(1): 78-101.
Luo J, Solimini NL, Elledge SJ. 2009. Principles of cancert herapy: oncogeneandnon-oncogene addiction. Cell. 136(5): 823-837.
Memmedov H, Aldemir O, Aliyev E. 2017. Propolisin antioksidan ve anti-inflamatuvar etkisi. Arıcılık Araştırma Dergisi. 9(2): 56-62.
Monteiro LDS, Bastos KX, Barbosa-Filho JM, de Athayde-Filho PF, Diniz MDFFM, Sobral MV. 2014. Medicinal plants and other living organisms with anti-tumor potential against lung cancer. Evidence-Based Complementary and Alternative Medicine. Article ID: 604152. http://dx.doi.org/10.1155/2014/604152.
Münstedt K, Bogdanov S. 2009. Bee products and their potentialuse in modern medicine. Journal of Api Productand Api Medical Science. 1(3): 57-63.
Nema R, Khare S, Jain P, Pradhan A, Gupta A, Singh D. 2013. Natural products potential and scope for modern cancer research. American Journal of Plant Sciences. 4(6): 1270-1277.
Oliveira PA, Colaço A, Chaves R, Guedes-Pinto H, De-La-Cruz P, Luis F, Lopes C. 2007. Chemical carcinogenesis. Anais da Academia Brasileira de Ciências. 79(4): 593-616.
Omene C, Kalac M, Wu J, Marchi E, Frenkel K, O’Connor OA. 2013. Propolis and its active component, caffeic acid phenethyl ester (CAPE), modulate breast cancer therapeu tictargetsvia an epigenetically mediated mechanism of action. Journal of Cancer Science &Therapy. 5(10): 334-352.
Onbaşlı D. 2019. Apiterapi ve insan sağlığı üzerine etkileri. Erciyes Üniversitesi Veteriner Fakültesi Dergisi.16(1): 49-56.
Patel S. 2016. Emerging adjuvant therapy for cancer: propolis and its constituents. Journal of Dietary Supplements. 13(3): 245-268.
Russo A, Cardile V, Sanchez F, Troncoso N, Vanella A, Garbarino JA. 2004. Chilean propolis: antioxidant activity and antiproliferative action in human tumor celll ines. Life Sciences. 76(5): 545-558.
Sağdıç O, Karasu S, Goktas H. 2020. Piyasada satılan ticari propolis örneklerinin biyoaktif bileşenlerinin belirlenmesi. Avrupa Bilim ve Teknoloji Dergisi. 19: 19-31.
Salatino A, Teixeira ÉW, Negri G. 2005. Origin and chemical variation of Brazilian propolis. Evidence-based Complementary and Alternative Medicine. 2(1): 33-38.
Sforcin JM. 2016. Biological properties and therapeutic applications of propolis. Phytotherapy Research, 30(6): 894-905.
Szliszka E, Czuba ZP, Bronikowska J, Mertas A, Paradysz A, Krol W. 2011. Ethanolic extract of propolis augments TRAIL-induced apoptotic death in prostate cancer cells. Evidence-Based Complementary and Alternative Medicine. Article ID: 535172. doi:10.1093/ecam/nep180.
Tan W, Lu J, Huang M, Li Y, Chen M, Wu G, Wang Y. 2011. Anti-cancer natural products isolated from chinese medicinal herbs. Chinese Medicine. 6(1): 1-15.
Toshiya K, Testuya T, Akira H, Takuji T. 2012. Cancer chemoprevention through the induction of apoptosis by natural compounds. Journal of Biophysical Chemistry. 3(2): 156-173.
Vatansever HS, Sorkun K, Gurhan SID, Ozdal-Kurt F, Turkoz E, Gencay O, Salih B. 2010. Propolis from Turkey induces apoptosis through activating caspases in human breast carcinoma cell lines. Acta Histochemica. 112(6): 546-556.
Vongsak B, Chonanant C, Machana S. 2017. In vitro ytotoxicity of Thai stingless bee propolis from Chanthaburi orchard. WalailakJ ournal of Scienceand Technology (WJST). 14(9): 741-747.
Vagish-Kumar LS. 2014. Propolis in dentistry and oral cancer management. North American Journal of Medical Sciences, 6(6): 250-259. doi: 10.4103/1947-2714.134369
Wagh VD. 2013. Propolis: a wonder bees productand its pharmacological potentials. Advances in pharmacological Sciences. Article ID: 308249. doi: https://doı.org/10.1155/2013/308249
Xuan H, Li Z, Yan H, Sang Q, Wang K, He Q, Hu F. 2014. Antitumor activity of Chinese propolis in human breast cancer MCF-7 and MDA-MB-231 cells. Evidence-Based Complementary and Alternative Medicine. Article ID: 280120. doi: http://dx.doi.org/10.1155/2014/280120
Yilmaz B, Erdal B. 2020. Anti-canceractivities of curcumin and propolis extracts on MCF-7 breast cancer cell line model. Medicine. 9(4): 877-84.
Yücel B, Topal E, Akçiçek E, Kösoğlu M. 2014 Propolisin insan sağlığına etkileri. Anadolu Ege Tarımsal Araştırma Enstitüsü Dergisi. 24(2): 41-49.
Zitvogel L, Apetoh L, Ghiringhelli F, Kroemer G. 2008. Immunological aspects of cancer chemotherapy. Nature Reviews Immunology. 8(1): 59-73.
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