Intestinal Permeability Targeted Rectal Enema Nutraceutical Intervention in Dogs with Cutaneous Adverse Food Reactions: Gut-Brain-Skin Axis Directed Pro-active Treatment

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  • Kerem Ural
  • Hasan Erdogan
  • Songul Erdogan
  • Tuğba Aslan
  • Cansu Balıkçı
  • Gamze Gökçay


Inflammatoric cutaneous disorders, Nutraceutical, Phytotherap, Polyphenol, Probiotic


Inflammatory cutaneous disorders have frequently been subjected to treatment trials with very limited success by pharmaceutical intervention, such as corticosteroids and non-steroidal anti-inflammatory drugs. Nevertheless, the latter drugs might be usual suspects for undesirable side effects. In an attempt to overcome those side effects, natural nutraceuticals are being investigated by the present researchers group. In this scenario, 5 different set of nutraceutical interventions [were numbered by their relevant usage order as Nutr-i1 to Nutr-i5] via rectal enema was deemed available at the present study as a novel protocol for pro-active treatment of cutaneous adverse food reactions (caFr) among dogs involved. In a total of 10 dogs with caFr, at the age of 2 to 7 years old, of both sexes, from various breeds diagnosis was based on i) in vitro serum testing for selected/specific IgE ii) intradermal testing different antigens, iii) elimination diet trial and iv) treatment based respond evaluation. Pruritus, as a vast majority presented clinical sign, scoring deemed available visual analog scale (pVaS). Mean (  ± Sd) pVaS scores showed significant decreases after treatment in contrast to prior values [1.4 ± 1.27 vs.7.7 ± 1.62, respectively (p<0.005)]. As discussed herein in the whole manuscript, all Nutr-i1 to Nutr-i5 protocols showed pro-active treatment efficacy, which could contribute to novel protocol establishment.


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How to Cite

Ural, K., Erdogan, H., Erdogan, S. ., Aslan, T., Balıkçı, C., & Gökçay, G. (2023). Intestinal Permeability Targeted Rectal Enema Nutraceutical Intervention in Dogs with Cutaneous Adverse Food Reactions: Gut-Brain-Skin Axis Directed Pro-active Treatment. International Journal of Veterinary and Animal Research (IJVAR), 6(1), 01–07. Retrieved from



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