Intestinal Permeability Targeted Rectal Enema Nutraceutical Intervention in Dogs with Cutaneous Adverse Food Reactions: Gut-Brain-Skin Axis Directed Pro-active TreatmentAbstract views: 87 / PDF downloads: 66
Keywords:Inflammatoric cutaneous disorders, Nutraceutical, Phytotherap, Polyphenol, Probiotic
Inflammatory cutaneous disorders have frequently been subjected to treatment trials with very limited success by pharmaceutical intervention, such as corticosteroids and non-steroidal anti-inflammatory drugs. Nevertheless, the latter drugs might be usual suspects for undesirable side effects. In an attempt to overcome those side effects, natural nutraceuticals are being investigated by the present researchers group. In this scenario, 5 different set of nutraceutical interventions [were numbered by their relevant usage order as Nutr-i1 to Nutr-i5] via rectal enema was deemed available at the present study as a novel protocol for pro-active treatment of cutaneous adverse food reactions (caFr) among dogs involved. In a total of 10 dogs with caFr, at the age of 2 to 7 years old, of both sexes, from various breeds diagnosis was based on i) in vitro serum testing for selected/specific IgE ii) intradermal testing different antigens, iii) elimination diet trial and iv) treatment based respond evaluation. Pruritus, as a vast majority presented clinical sign, scoring deemed available visual analog scale (pVaS). Mean ( ± Sd) pVaS scores showed significant decreases after treatment in contrast to prior values [1.4 ± 1.27 vs.7.7 ± 1.62, respectively (p<0.005)]. As discussed herein in the whole manuscript, all Nutr-i1 to Nutr-i5 protocols showed pro-active treatment efficacy, which could contribute to novel protocol establishment.
Abdel kader HA., Seddek S, El-Shanawany AA. 1995. In vitro study of the effect of some medicinal plants on the growth of some dermatophytes. Assiut Veterinary Medical Journal, 34(67): 36-42.
Agaba A, Cheng H, Zhao J, Zhang C, Tebyetekerwa M, Rong L, Wang B. 2018. Precipitated silica agglomerates reinforced with cellulose nanofibrils as adsorbents for heavy metals. RSC Advances, 8(58): 33129-33137.
Aitoro, R., Paparo, L., Amoroso, A., Di Costanzo, M., Cosenza, L., Granata, V., ... & Berni Canani, R. (2017). Gut microbiota as a target for preventive and therapeutic intervention against food allergy. Nutrients, 9(7), 672.
Ali SA, Meitei KV. 2011. Nigella sativa seed extract and its bioactive compound thymoquinone: the new melanogens causing hyperpigmentation in the wall lizard melanophores. Journal of Pharmacy and Pharmacology, 63(5): 741-746.
Aljabre SHM, Randhawa MA, Akhtar N, Alakloby OM, Alqurashi AM, Aldossary A. 2005. Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone. Journal of Ethnopharmacology, 101(1-3): 116-119.
Al-Noor T. 2017. Physicochemical Properties of Pumpkin Seed Oil & Therapy of Inflammatory Facial Acne Vulgaris. International Journal of Science and Research (IJSR), 6: 1747-1754.
Augustine, T., Kumar, M., Al Khodor, S., & van Panhuys, N. (2022). Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes. Clinical Reviews in Allergy & Immunology, 1-29.
Bethlehem S, Bexley J, Mueller RS. 2012. Patch testing and allergen-specific serum IgE and IgG antibodies in the diagnosis of canine adverse food reactions. Veterinary Immunology and Immunopathology, 145(3-4): 582-589.
Castangia I, Caddeo C, Manca ML, Casu L, Latorre AC, Díez-Sales O, Manconi M. 2015. Delivery of liquorice extract by liposomes and hyalurosomes to protect the skin against oxidative stress injuries. Carbohydrate Polymers, 134: 657-663.
Craig, J. M. (2016). Atopic dermatitis and the intestinal microbiota in humans and dogs. Veterinary Medicine and Science, 2(2), 95-105.
Danilova I, Sharipova M. 2020. The practical potential of bacilli and their enzymes for industrial production. Frontiers in Microbiology, 11: 1782.
De Pessemier, B., Grine, L., Debaere, M., Maes, A., Paetzold, B., & Callewaert, C. (2021). Gut–skin axis: current knowledge of the interrelationship between microbial dysbiosis and skin conditions. Microorganisms, 9(2), 353.
Detman A, Mielecki D, Chojnacka A, Salamon A, Błaszczyk MK, Sikora A. 2019. Cell factories converting lactate and acetate to butyrate: Clostridium butyricum and microbial communities from dark fermentation bioreactors. Microbial Cell Factories, 18(1): 1-12.
Di Marzio L, Cinque B, De Simone C, Cifone MG. 1999. Effect of the lactic acid BacteriumStreptococcus thermophilus on ceramide levels in human KeratinocytesIn vitro and stratum corneum in vivo. Journal of Investigative Dermatology, 113(1): 98-106.
Duncan SH, Louis P, Flint HJ. 2004. Lactate-utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product. Applied and Environmental Microbiology, 70(10): 5810-5817.
Edelstein A, Fink D, Musch M, Valuckaite V, Zaborina O, Grubjesic S, Alverdy JC. 2011. Protective effects of nonionic tri-block copolymers on bile acid-mediated epithelial barrier disruption. Shock, 36(5): 451.
Esfandiari A, Kelly AP. 2005. The effects of tea polyphenolic compounds on hair loss among rodents. Journal of the National Medical Association. 97(8): 1165–1169.
Eslami, M., Bahar, A., Keikha, M., Karbalaei, M., Kobyliak, N. M., & Yousefi, B. (2020). Probiotics function and modulation of the immune system in allergic diseases. Allergologia et Immunopathologia, 48(6), 771-788.
Fahey JW, Talalay P. 1999. Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes. Food and Chemical Toxicology, 37(9): 973-979.
Feng W, Wu Y, Chen G, Fu S, Li B, Huang B, Liu J. 2018. Sodium butyrate attenuates diarrhea in weaned piglets and promotes tight junction protein expression in colon in a GPR109A-dependent manner. Cellular Physiology and Biochemistry, 47(4): 1617-1629.
Foster, A. P., Knowles, T. G., Moore, A. H., Cousins, P. D. G., Day, M. J., & Hall, E. J. (2003). Serum IgE and IgG responses to food antigens in normal and atopic dogs, and dogs with gastrointestinal disease. Veterinary immunology and immunopathology, 92(3-4), 113-124.
Hillier, A., & Griffin, C. E. (2001). The ACVD task force on canine atopic dermatitis (X): is there a relationship between canine atopic dermatitis and cutaneous adverse food reactions?. Veterinary immunology and immunopathology, 81(3-4), 227-231.
Izzo AA, Fezza F, Capasso R, Bisogno T, Pinto L, Iuvone T, Capasso F. 2001. Cannabinoid CB1‐receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation. British Journal of Pharmacology, 134(3): 563-570.
Kelly CJ, Zheng L, Campbell EL, Saeedi B, Scholz CC, Bayless AJ, Colgan SP. 2015. Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function. Cell Host & Microbe, 17(5): 662-671.
Kerem, U. R. A. L. (2022). Fecal microbiota transplantation capsule therapy via oral route for combatting atopic dermatitis in dogs. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 69(2), 211-219.
Kerns ML, DePianto D, Dinkova-Kostova AT, Talalay P, Coulombe PA. 2007. Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex. Proceedings of the National Academy of Sciences, 104(36): 14460-14465.
Kotian S, Bhat K, Pai S, Nayak J, Souza A, Gourisheti K, Padma D. 2018. The role of natural medicines on wound healing: A biomechanical, histological, biochemical and molecular study. Ethiopian Journal of Health Sciences, 28: 759–770.
Kwon OS, Han JH, Yoo HG, Chung JH, Cho KH, Eun HC, Kim KH. 2007. Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG). Phytomedicine, 14(7-8): 551-555.
Li S, Yue X, Jing Y, Bai S, Dai Z. 2011. Fabrication of zonal thiol-functionalized silica nanofibers for removal of heavy metal ions from wastewater. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 380(1-3): 229-233.
Lunjani, N., Satitsuksanoa, P., Lukasik, Z., Sokolowska, M., Eiwegger, T., & O'Mahony, L. (2018). Recent developments and highlights in mechanisms of allergic diseases: Microbiome. Allergy, 73(12), 2314-2327.
Massa F, Marsicano G, Hermann H, Cannich A, Monory K, Cravatt BF, Lutz B. 2004. The endogenous cannabinoid system protects against colonic inflammation. The Journal of clinical investigation, 113(8): 1202-1209.
Mostafa DM, Ammar NM, Abd El-Alim SH, El-anssary AA. 2014. Transdermal microemulsions of Glycyrrhiza glabra L.: characterization, stability and evaluation of antioxidant potential. Drug Delivery, 21(2): 130-139.
Mueller RS, Olivry T. 2017. Critically appraised topic on adverse food reactions of companion animals (4): can we diagnose adverse food reactions in dogs and cats with in vivo or in vitro tests?. BMC Veterinary Research, 13(1): 1-5.
Mueller, R. S., & Unterer, S. (2018). Adverse food reactions: Pathogenesis, clinical signs, diagnosis and alternatives to elimination diets. The Veterinary Journal, 236, 89-95.
Nagarkatti P, Pandey R, Rieder SA, Hegde VL, Nagarkatti M. 2009. Cannabinoids as novel anti-inflammatory drugs. Future Medicinal Chemistry, 1(7): 1333-1349.
emser, S. M., Doran, T., Grabenstein, M., McConnell, T., McGrath, T., Pamboukian, R., ... & Reimschuessel, R. (2014). Investigation of Listeria, Salmonella, and toxigenic Escherichia coli in various pet foods. Foodborne pathogens and disease, 11(9), 706-709.
Ogawa T, Okumura R, Nagano K, Minemura T, Izumi M, Motooka D, Takeda K. 2021. Oral intake of silica nanoparticles exacerbates intestinal inflammation. Biochemical and Biophysical Research Communications, 534: 540-546.
Ohata A, Usami M, Miyoshi M. 2005. Short-chain fatty acids alter tight junction permeability in intestinal monolayer cells via lipoxygenase activation. Nutrition, 21(7-8): 838-847.
Olivry T, Mueller RS. 2017. Critically appraised topic on adverse food reactions of companion animals (3): prevalence of cutaneous adverse food reactions in dogs and cats. BMC Veterinary Research, 13(51): 017–0973.
Olivry, T., DeBoer, D. J., Prélaud, P., Bensignor, E., & International Task Force on Canine Atopic Dermatitis. (2007). Food for thought: pondering the relationship between canine atopic dermatitis and cutaneous adverse food reactions. Veterinary Dermatology, 18(6), 390-391.
Olsen DL, Raub W, Bradley C, Johnson M, Macias JL, Love V, Markoe A. 2001). The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. Oncology Nursing Forum, 28:3.
Pastorino G, Cornara L, Soares S, Rodrigues F, Oliveira MBPP. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy Research, 32: 2323–2339.
Pavicic T, Wollenweber U, Farwick M, Korting HC. 2007. Anti‐microbial and‐inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris. International Journal of Cosmetic Science, 29(3): 181-190.
Pertwee RG. 2001. Cannabinoids and the gastrointestinal tract. Gut, 48(6): 859-867.
Picco, F., Zini, E., Nett, C., Naegeli, C., Bigler, B., Rüfenacht, S., ... & Favrot, C. (2008). A prospective study on canine atopic dermatitis and food‐induced allergic dermatitis in Switzerland. Veterinary Dermatology, 19(3), 150-155.
Pucheu‐Haston, C. M., & Mougeot, I. (2020). Serum IgE and IgG responses to dietary antigens in dogs with and without cutaneous adverse food reactions. Veterinary dermatology, 31(2), 116-e20.
Ricci R, Granato A, Vascellari M, Boscarato M, Palagiano C, Andrighetto I, Mutinelli F. 2013. Identification of undeclared sources of animal origin in canine dry foods used in dietary elimination trials. Journal of Animal Physiology and Animal Nutrition, 97: 32-38.
Rostaher, A., Morsy, Y., Favrot, C., Unterer, S., Schnyder, M., Scharl, M., & Fischer, N. M. (2022). Comparison of the Gut Microbiome between Atopic and Healthy Dogs—Preliminary Data. Animals, 12(18), 2377.
Royal, C., & Gray, C. (2020). Focus: Allergic Diseases and Type II Immunity: Allergy Prevention: An Overview of Current Evidence. The Yale Journal of Biology and Medicine, 93(5), 689.
Salem ML, Hossain MS. 2000. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. International Journal of Immunopharmacology, 22(9): 729-740.
Salzman, N. H. (2014). The role of the microbiome in immune cell development. Annals of Allergy, Asthma & Immunology, 113(6), 593-598.
Shimakura H, Kawano K. 2021. Results of food challenge in dogs with cutaneous adverse food reactions. Veterinary Dermatology, 32(3): 293-e80.
Shimakura, H., & Kawano, K. (2021). Results of food challenge in dogs with cutaneous adverse food reactions. Veterinary Dermatology, 32(3), 293-e80.
Simmler C, Pauli GF, Chen SN. 2013. Phytochemistry and biological properties of glabridin. Fitoterapia, 90: 160–184.
Swartzendruber JA, Incrocci RW, Wolf SA, Jung A, Knight KL. 2019. Bacillus subtilis exopolysaccharide prevents allergic eosinophilia. Allergy, 74(4): 819.
Tabassum N, Hamdani M. 2014. Plants used to treat skin diseases. Pharmacognosy Reviews, 8(15): 52.
Talalay P, Fahey JW, Healy ZR, Wehage SL, Benedict AL, Min C, Dinkova-Kostova AT. 2007. Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation. Proceedings of the National Academy of Sciences, 104(44): 17500-17505.
Ural K, Erdoğan H, Erdoğan S, Çamkerten İ, Şahin N. 2021a. Circulating Serum Zonulin Levels Before and After Probiotic Enema Treatment in Dogs with Atopic Dermatitis: Randomized Clinical Study Turkiye Klinikleri Journal of Veterinary Sciences, 12(2): 70-78.
Ural K, Erdoğan H, Erdoğan S, İçaçan ŞG, Akbaş C. 2021b. Vital-supporting new therapy in dogs with systemic inflammatory response syndrome and possible bacterial translocation: application of high-volume polyethylene glycol with proctolysis, Journal of Advances in VetBio Science and Techniques, 6(1):39-44.
Ural K, Erdoğan S, Balıkçı C, Erdoğan H, İçaçan ŞG. 2021b. Inovatif Gastroentero-Dermatoloji Kapsamında Muhtelif Yöntem Geliştirme I: Lactobacillus plantarum ve Lactobacillus paracasei ile Probiyotik Eneması Atopik Dermatitli Köpeklerde Anti-Pruritik Etkinlik Sağlar Mı?. Van Veterinary Journal, 32(2): 74-81 .
Ural K, Gultekin M, Erdogan H, Erdoğan S, Gül G, Türk E. 2020. Could Short-Term Altered Calendar Probiotic Treatment Relieve Itching in Dogs with Atopic Dermatitis?. Turkiye Klinikleri Journal of Veterinary Sciences, 11:1-8.
Valuckaite V, Zaborina O, Long J, Hauer-Jensen M, Wang J, Holbrook C, Alverdy JC. 2009. Oral PEG 15–20 protects the intestine against radiation: role of lipid rafts. American Journal of Physiology-Gastrointestinal and Liver Physiology, 297(6): 1041-1052.
Wang, X., Zhang, P., & Zhang, X. (2021). Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity. Molecules, 26(19), 6076.
Wood JD, Alpers DH, Andrews PLR. 1999. Fundamentals of neurogastroenterology. Gut, 45(2): 6-16.
Xu HX, Wan M, Loh BN, Kon OL, Chow PW, Sim KY. 1996. Screening of traditional medicines for their inhibitory activity against HIV‐1 protease. Phytotherapy Research, 10(3): 207-210.
Yan H, Ajuwon KM. 2017. Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway. PloS One, 12(6): e0179586.
Yazdi AS, Guarda G, Riteau N, Drexler SK, Tardivel A, Couillin I, Tschopp J. 2010. Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β. Proceedings of the National Academy of Sciences, 107(45): 19449-19454.
Yu H, Li H, Li Y, Li M, Chen G. 2017. Effect of isoliquiritigenin for the treatment of atopic dermatitis-like skin lesions in mice. Archives of Dermatological Research, 309: 805–813.
Zamora-Pineda J, Kalinina O, Osborne BA, Knight KL. 2022. Probiotic Molecules That Inhibit Inflammatory Diseases. Applied Sciences, 12(3): 1147.
How to Cite
Copyright (c) 2023 International Journal of Veterinary and Animal Research (IJVAR)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.