Alterations in Gut Integrity Due to Heat Stress Among Dairy Cattle of Aydin City: Analytical Interpretation of Zonulin Levels Within Repetitive Measurements

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intestinal dysfunction, heat stress, lactaton cattle, zonulin


Animal health and production are impaired with heat stress inducing dysfunction of intestinal barrier. In this study, it was aimed to determine that the effect of heat stress on gut health via circulating zonulin concentrations. Holstein dairy cows (n=7, age of 2-5 years) were housed in Aydin municipality with higher temperatures in summer. Blood sample for serum zonulin levels were collected at 12 pm and 00 am with temperature records of 44°C and 31°C respectively. Serum zonulin levels were found to be statistically significant (p=0,012) at night in contrast to daylight analytes. With this study it was appeared that heat stress had a negatively impact on intestinal integrity among cows.

Author Biographies

Deniz Alıc Ural, Assoc. Prof. Dr.

Aydin Adnan Menderes University, Veterinary Faculty, Animal Farm, Aydin, Turkey

Kerem Ural, Prof. Dr.

Aydin Adnan Menderes University, Veterinary Faculty, Department of Internal Medicine, Aydin, Turkey

Hasan Erdogan, Assoc. Prof. Dr.

Aydin Adnan Menderes University, Veterinary Faculty, Department of Internal Medicine, Aydin, Turkey

Songul Erdogan, Assoc. Prof. Dr.

Aydin Adnan Menderes University, Veterinary Faculty, Department of Internal Medicine, Aydin, Turkey


Anonymous 1. Web site access:]. Access date: 07.08.2021

Anonymous 2. Web site access:]. Access date: 07.08.2021

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How to Cite

Alıc Ural, D., Ural, K., Erdogan, H., & Erdogan, S. (2021). Alterations in Gut Integrity Due to Heat Stress Among Dairy Cattle of Aydin City: Analytical Interpretation of Zonulin Levels Within Repetitive Measurements. International Journal of Veterinary and Animal Research (IJVAR), 4(3), 111–114. Retrieved from



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