Alterations in Gut Integrity Due to Heat Stress Among Dairy Cattle of Aydin City: Analytical Interpretation of Zonulin Levels Within Repetitive Measurements

Abstract views: 83 / PDF downloads: 44

Authors

Keywords:

intestinal dysfunction, heat stress, lactaton cattle, zonulin

Abstract

Animal health and production are impaired with heat stress inducing dysfunction of intestinal barrier. In this study, it was aimed to determine that the effect of heat stress on gut health via circulating zonulin concentrations. Holstein dairy cows (n=7, age of 2-5 years) were housed in Aydin municipality with higher temperatures in summer. Blood sample for serum zonulin levels were collected at 12 pm and 00 am with temperature records of 44°C and 31°C respectively. Serum zonulin levels were found to be statistically significant (p=0,012) at night in contrast to daylight analytes. With this study it was appeared that heat stress had a negatively impact on intestinal integrity among cows.

Author Biographies

Deniz Alıc Ural, Assoc. Prof. Dr.

Aydin Adnan Menderes University, Veterinary Faculty, Animal Farm, Aydin, Turkey

Kerem Ural, Prof. Dr.

Aydin Adnan Menderes University, Veterinary Faculty, Department of Internal Medicine, Aydin, Turkey

Hasan Erdogan, Assoc. Prof. Dr.

Aydin Adnan Menderes University, Veterinary Faculty, Department of Internal Medicine, Aydin, Turkey

Songul Erdogan, Assoc. Prof. Dr.

Aydin Adnan Menderes University, Veterinary Faculty, Department of Internal Medicine, Aydin, Turkey

References

Anonymous 1. Web site access: https://tr.climatedata.org/asya/tuerkiye/ayd%C4%B1n/ayd%C4%B1n-178/t/eyl%C3%BCl-9/]. Access date: 07.08.2021

Anonymous 2. Web site access: https://www.accuweather.com/tr/tr/aydin/317040/august-weather/317040?year=2021]. Access date: 07.08.2021

Assimakopoulos SF, Gogos C, Labropoulou-Karatza C. 2011 Could antioxidants be the “magic pill” for cirrhosis-related complications? A pathophysiological appraisal. Med Hypotheses, 77(3): 419-423.

Baker JW, Deitch EA, Li M, Berg RD, Specian RD. 1988. Hemorrhagic shock induces bacterial translocation from the gut. J Trauma, 28(7): 896-906.

Bosenberg AT, Brock-Utne JG, Gaffin SL, Wells MT, Blake GT. 1988. Strenuous exercise causes systemic endotoxemia. J Appl Physiol, 65(1): 106-108.

Di Pierro M, Lu R, Uzzau S, Wang W, Margaretten K, Pazzani C, Fasano A. 2001. Zonula occludens toxin structure-function analysis Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain. J Biol Chem, 276(22): 19160-19165.

Dokladny K, Moseley PL, Ma TY. 2006. Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability. American Am J Physiol Gastrointest Liver Physiol. 290(2): 204-212.

Elson CO, Cong Y. 2012. Host-microbiota interactions in inflammatory bowel disease. Gut microbes, 3(4): 332-344.Farag MR, Alagawany M. Physiological alterations of poultry to the high environmental temperature. J Therm Biol. 2018; 76: 101-106.

Farquhar MG, Palade GE. 1963. Junctional complexes in various epithelia. The Journal of cell biology, 17(2): 375-412.

Goto Y, Ivanov II. 2013. Intestinal epithelial cells as mediators of the commensal-host immune crosstalk. Immunol Cell Biol, 91: 204–214.

Hall DM, Buettner GR, Oberley LW, Xu L, Matthes RD, Gisolfi CV. 2001. Mechanisms of circulatory and intestinal barrier dysfunction during whole bodyhyperthermia. Am J Physiol Heart Circ, 280(2): 509-521.

Hollander D. 1988. Crohn's disease--a permeability disorder of the tight junction?. Gut, 29(12): 1621.

Ilan Y. 2012. Leaky gut and the liver: A role for bacterial translocation in nonalcoholic steatohepatitis. World J Gastroenterol. 18(21): 2609.

Karl TR, Trenberth KE. 2003. Modern global climate change. Science, 302(5651): 1719-1723.

Kaya, Y, Bilgehan Aydın, G. 2017. İklim Değişikliğinin Aydın Yöresinde Toprak Nemi Üzerindeki Etkileri ve SWAP Modeli ile Simülasyonu. Toprak Su Dergisi, 31-45.

King MA, Clanton TL, Laitano O. 2016. Hyperthermia, dehydration, and osmotic stress: unconventional sources of exercise-induced reactive oxygen species. Am J Physiol Regul Integr Comp Physiol, 310(2):105-1014.

King MA, Rollo I, Baker LB. 2021. Nutritional Considerations to Counteract Gastrointestinal Permeability during Exertional Heat Stress. J Appl Physiol, 130; 6: 1754-1765.

Koch F, Thom U, Albrecht E, Weikard R, Nolte W, Kuhla B, Kuehn C. 2019. Heat stress directly impairs gut integrity and recruits distinct immune cell populations into the bovine intestine. PNAS, 116(21): 10333-10338.

Koh TS, Peng RK, Klasing KC. 1996. Dietary copper level affects copper metabolism during lipopolysaccharide-induced immunological stress in chicks. Poult Sci J, 75(7): 867-872.

Lambert GP, Gisolfi CV, Berg DJ, Moseley PL, Oberley LW, Kregel KC. 1985. Selected contribution: hyperthermia-induced intestinal permeability and the role of oxidative and nitrosative stress. J Appl Physiol, 92: 1750–1761.

Lara LJ, Rostagno MH. 2013. Impact of heat stress on poultry production. Animals, 3(2): 356-369.

Lian P, Braber S, Garssen J, Wichers HJ, Folkerts G, Fink-Gremmels J, Varasteh S. 2020. Beyond heat stress: Intestinal integrity disruption and mechanism-based intervention strategies. Nutrients, 12(3): 734.

Maejima K, Deitch EA, Berg RD. 1984. Bacterial translocation from the gastrointestinal tracts of rats receiving thermal injury. Infect Immun, 43(1): 6-10.

Pearce SC, Mani V, Weber TE, Rhoads RP, Patience JF, Baumgard LH, Gabler NK. 2013. Heat stress and reduced plane of nutrition decreases intestinal integrity and function in pigs. J Anim Sci, 91(11): 5183-5193.

Ribet D, Cossart P. 2015. How bacterial pathogens colonize their hosts and invade deeper tissues. Microbes Infect, 17(3): 173-183.Salzman NH. Microbiota–immune system interaction: an uneasy alliance. Curr Opin Microbiol. 2011; 14(1): 99-105.

Suzuki K, Harasawa R, Yoshitake Y, Mitsuoka T. 1983. Effects of crowding and heat stress on intestinal flora, body weight gain, and feed efficiency of growing rats and chicks. Nihon Juigaku Zasshi, 45(3): 331-338.

Tellez Jr. G, Tellez-Isaias G, Dridi S. 2017. Heat stress and gut health in broilers: Role of tight junction proteins. Adv Food Technol Nutr Sci Open J, 3(1): 1-4.

Wang X, Gao,H, Gebremedhin KG, Bjerg BS, Van Os J, Tucker CB, Zhang G. 2018. A predictive model of equivalent temperature index for dairy cattle (ETIC). J of Therm Biol, 76: 165-170.

West JW. 2003. Effects of heat-stress on production in dairy cattle. J Dairy Sci, 86(6): 2131-2144.

Downloads

Published

2021-12-14

How to Cite

Alıc Ural, D., Ural, K., Erdogan, H., & Erdogan, S. (2021). Alterations in Gut Integrity Due to Heat Stress Among Dairy Cattle of Aydin City: Analytical Interpretation of Zonulin Levels Within Repetitive Measurements. International Journal of Veterinary and Animal Research (IJVAR), 4(3), 111–114. Retrieved from https://ijvar.org/index.php/ijvar/article/view/516

Issue

Section

Research Articles