Sub-Lethal Effects of Heavy Metals Toxicity on Pathological Lesions of Sea Bream

Abstract views: 151 / PDF downloads: 162


  • Aliakbar Hedayati


Cell, Fish; Histopathology; Mercury; Toxicology


Histopathological indices have been largely used as biomarkers in the monitoring of fish health status during exposure to heavy metals, both in
the experimental and environmental studies. The aims of the present study was to provide baseline data on the prevalence of histopathological
liver lesions in marine fishes (case study of liver histopathology at mercury exposure) under experimental mercury exposure and to compare
the sampling areas in terms of the types and prevalence of lesions present, for monitoring purposes. Experimental study was at seawater
re-circulatory tanks. Mercury concentrations were determined using a standard cold vapor atomic absorption. Histopathological analyses were
done in tissue processor and the slides were stained with haematoxylin and counter stained with eosin. There were many liver lesions in both
area include enlarged and lateral nuclei, nuclear degeneration and vacuolation; oncotic, apoptic, focal, massive, centrilobular and periportal
necrosis; atrophy, lipidosis, hydropic and cloudy swelling, oval cell proliferation; bile stagnation, dilation of sinusoid, intracellular edema
and dark granules. In conclusion the present investigation indicated that mercury is a toxic substance in seabream and the sub-lethal mercury
concentrations tested may cause several changes in the histological indices of the studied fish and we can use these changes as biomarkers of
mercury detection.




How to Cite

Hedayati, A. (2018). Sub-Lethal Effects of Heavy Metals Toxicity on Pathological Lesions of Sea Bream. International Journal of Veterinary and Animal Research (IJVAR), 1(3), 1–7. Retrieved from



Research Articles